	   SnapGene      #<acgcgtgtagtcttatgcaatactcttgtagtcttgcaacatggtaacgatgagttagcaacatgccttacaaggagagaaaaagcaccgtgcatgccgattggtggaagtaaggtggtacgatcgtgccttattaggaaggcaacagacgggtctgacatggattggacgaaccactgaattgccgcattgcagagatattgtatttaagtgcctagctcgatacaataaacgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtggcgcccgaacagggacctgaaagcgaaagggaaaccagagctctctcgacgcaggactcggcttgctgaagcgcgcacggcaagaggcgaggggcggcgactggtgagtacgccaaaaattttgactagcggaggctagaaggagagagatgggtgcgagagcgtcagtattaagcgggggagaattagatcgcgatgggaaaaaattcggttaaggccagggggaaagaaaaaatataaattaaaacatatagtatgggcaagcagggagctagaacgattcgcagttaatcctggcctgttagaaacatcagaaggctgtagacaaatactgggacagctacaaccatcccttcagacaggatcagaagaacttagatcattatataatacagtagcaaccctctattgtgtgcatcaaaggatagagataaaagacaccaaggaagctttagacaagatagaggaagagcaaaacaaaagtaagaccaccgcacagcaagcggccactgatcttcagacctggaggaggagatatgagggacaattggagaagtgaattatataaatataaagtagtaaaaattgaaccattaggagtagcacccaccaaggcaaagagaagagtggtgcagagagaaaaaagagcagtgggaataggagctttgttccttgggttcttgggagcagcaggaagcactatgggcgcagcctcaatgacgctgacggtacaggccagacaattattgtctggtatagtgcagcagcagaacaatttgctgagggctattgaggcgcaacagcatctgttgcaactcacagtctggggcatcaagcagctccaggcaagaatcctggctgtggaaagatacctaaaggatcaacagctcctggggatttggggttgctctggaaaactcatttgcaccactgctgtgccttggaatgctagttggagtaataaatctctggaacagattggaatcacacgacctggatggagtgggacagagaaattaacaattacacaagcttaatacactccttaattgaagaatcgcaaaaccagcaagaaaagaatgaacaagaattattggaattagataaatgggcaagtttgtggaattggtttaacataacaaattggctgtggtatataaaattattcataatgatagtaggaggcttggtaggtttaagaatagtttttgctgtactttctatagtgaatagagttaggcagggatattcaccattatcgtttcagacccacctcccaaccccgaggggacccgacaggcccgaaggaatagaagaagaaggtggagagagagacagagacagatccattcgattagtgaacggatctcgacggtatcggttaacttttaaaagaaaaggggggattggggggtacagtgcaggggaaagaatagtagacataatagcaacagacatacaaactaaagaattacaaaaacaaattacaaaaattcaaaattttatcgatactagtaaggatctgcgatcgctccggtgcccgtcagtacgccttctgtatgaaacagtttttcctccacgccttctgtatgaaacagtttttcctccacgccttctgtatgaaacagtttttcctccacgccttctgtatgaaacagtttttcctcctcgaggacattttgacacccccataatatttttccagaattaacagtataaattgcatctcttgttcaagagttccctatcactctctttaatcactactcacagtaacctcaactcctgcccaagcttcaagctgtgaccggcgcctactctagagctagcgaattcatggaagatgccaaaaacattaagaagggcccagcgccattctacccactcgaagacgggaccgccggcgagcagctgcacaaagccatgaagcgctacgccctggtgcccggcaccatcgcctttaccgacgcacatatcgaggtggacattacctacgccgagtacttcgagatgagcgttcggctggcagaagctatgaagcgctatgggctgaatacaaaccatcggatcgtggtgtgcagcgagaatagcttgcagttcttcatgcccgtgttgggtgccctgttcatcggtgtggctgtggccccagctaacgacatctacaacgagcgcgagctgctgaacagcatgggcatcagccagcccaccgtcgtattcgtgagcaagaaagggctgcaaaagatcctcaacgtgcaaaagaagctaccgatcatacaaaagatcatcatcatggatagcaagaccgactaccagggcttccaaagcatgtacaccttcgtgacttcccatttgccacccggcttcaacgagtacgacttcgtgcccgagagcttcgaccgggacaaaaccatcgccctgatcatgaacagtagtggcagtaccggattgcccaagggcgtagccctaccgcaccgcaccgcttgtgtccgattcagtcatgcccgcgaccccatcttcggcaaccagatcatccccgacaccgctatcctcagcgtggtgccatttcaccacggcttcggcatgttcaccacgctgggctacttgatctgcggctttcgggtcgtgctcatgtaccgcttcgaggaggagctattcttgcgcagcttgcaagactataagattcaatctgccctgctggtgcccacactatttagcttcttcgctaagagcactctcatcgacaagtacgacctaagcaacttgcacgagatcgccagcggcggggcgccgctcagcaaggaggtaggtgaggccgtggccaaacgcttccacctaccaggcatccgccagggctacggcctgacagaaacaaccagcgccattctgatcacccccgaaggggacgacaagcctggcgcagtaggcaaggtggtgcccttcttcgaggctaaggtggtggacttggacaccggtaagacactgggtgtgaaccagcgcggcgagctgtgcgtccgtggccccatgatcatgagcggctacgttaacaaccccgaggctacaaacgctctcatcgacaaggacggctggctgcacagcggcgacatcgcctactgggacgaggacgagcacttcttcatcgtggaccggctgaagagcctgatcaaatacaagggctaccaggtagccccagccgaactggagagcatcctgctgcaacaccccaacatcttcgacgccggggtcgccggcctgcccgacgacgatgccggcgagctgcccgccgcagtcgtcgtgctggaacacggtaaaaccatgaccgagaaggagatcgtggactatgtggccagccaggttacaaccgccaagaagctgcgcggtggtgttgtgttcgtggacgaggtgcctaaaggactgaccggcaagttggacgcccgcaagatccgcgagattctcattaaggccaagaagggcggcaagatcgccgtgtgataggcggccgcGAATTCTAATCTAGAACGCGATtaattctaccgggtaggggaggcgcttttcccaaggcagtctggagcatgcgctttagcagccccgctgggcacttggcgctacacaagtggcctctggcctcgcacacattccacatccaccggtaggcgccaaccggctccgttctttggtggccccttcgcgccaccttctactcctcccctagtcaggaagttcccccccgccccgcagctcgcgtcgtgcaggacgtgacaaatggaagtagcacgtctcactagtctcgtgcagatggacagcaccgctgagcaatggaagcgggtaggcctttggggcagcggccaatagcagctttgctccttcgctttctgggctcagaggctgggaaggggtgggtccgggggcgggctcaggggcgggctcaggggcggggcgggcgcccgaaggtcctccggaggcccggcattctgcacgcttcgaagcgcacgtctgccgcgctgttctcctcttcctcatctccgggcctttcgaATTCAAGGGCAGAGGAAGTCTTCTAACTTGAGGTGACGTGGAGGAGAATCCCGGCCCTATGACCGAGTACAAGCCCACGGTGCGCCTCGCCACCCGCGACGACGTCCCCAGGGCCGTACGCACCCTCGCCGCCGCGTTCGCCGACTACCCCGCCACGCGCCACACCGTCGATCCGGACCGCCACATCGAGCGGGTCACCGAGCTGCAAGAACTCTTCCTCACGCGCGTCGGGCTCGACATCGGCAAGGTGTGGGTCGCGGACGACGGCGCCGCGGTGGCGGTCTGGACCACGCCGGAGAGCGTCGAAGCGGGGGCGGTGTTCGCCGAGATCGGCCCGCGCATGGCCGAGTTGAGCGGTTCCCGGCTGGCCGCGCAGCAACAGATGGAAGGCCTCCTGGCGCCGCACCGGCCCAAGGAGCCCGCGTGGTTCCTGGCCACCGTCGGCGTCTCGCCCGACCACCAGGGCAAGGGTCTGGGCAGCGCCGTCGTGCTCCCCGGAGTGGAGGCGGCCGAGCGCGCCGGGGTGCCCGCCTTCCTGGAGACCTCCGCGCCCCGCAACCTCCCCTTCTACGAGCGGCTCGGCTTCACCGTCACCGCCGACGTCGAGGTGCCCGAAGGACCGCGCACCTGGTGCATGACCCGCAAGCCCGGTGCCTGAgtcgacaatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaaatcatcgtcctttccttggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtcttcgccttcgccctcagacgagtcggatctccctttgggccgcctccccgcctggtacctttaagaccaatgacttacaaggcagctgtagatcttagccactttttaaaagaaaaggggggactggaagggctaattcactcccaacgaaaataagatctgctttttgcttgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtagtagttcatgtcatcttattattcagtatttataacttgcaaagaaatgaatatcagagagtgagaggaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctggctctagctatcccgcccctaactccgcccagttccgcccattctccgccccatggctgactaattttttttatttatgcagaggccgaggccgcctcggcctctgagctattccagaagtagtgaggaggcttttttggaggcctagacttttgcagagacggcccaaattcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaaggacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtctaagaaaccattattatcatgacattaacctataaaaataggcgtatcacgaggccctttcgtctcgcgcgtttcggtgatgacggtgaaaacctctgacacatgcagctcccggagacggtcacagcttgtctgtaagcggatgccgggagcagacaagcccgtcagggcgcgtcagcgggtgttggcgggtgtcggggctggcttaactatgcggcatcagagcagattgtactgagagtgcaccatatgcggtgtgaaataccgcacagatgcgtaaggagaaaataccgcatcaggcgccattcgccattcaggctgcgcaactgttgggaagggcgatcggtgcgggcctcttcgctattacgccagctggcgaaagggggatgtgctgcaaggcgattaagttgggtaacgccagggttttcccagtcacgacgttgtaaaacgacggccagtgccaagctg  Ly   -   *      1   )   1      #   3            6   %   6   4   *   -      /   7   -                  /   $   )          2      #   1               #                        1         6   5   7      !   <   #   /   1   *   1   4   9   ,   ,      2   -   6   +      "   %   "      )   7   4      :   6      -   1   P   )   #      (   (         %       "                  !             %      "       *   "                #   (   .                     ,   &         '   /   -   *   "             +               *   '   4                  $               "                  $         +      %                5   $   *   $   &   )            "   *      *   "   1      '   $         )   !   $      "   8   +         %   !   
         '   $   .   E   %   /   (   8   5   ,      %   "      !   *            .   ?   "   %   ,               !      ,   9      /   +   +   *   #      C   -         ,   *      /   *   4   #      -        - ûQR}~Ú%§!"#0~óFr™ÒÝÞêöû–—iíU~‡ˆ‰L¹;ï+ =!+"ä"å"* ¬½Sf«î½-K�{¨1	ÿ
ôÉsÍ¸Šã÷Œº<9äƒî» ú!²"æ" – é 8C&$ã	ÚFGm�Ó× \5jÄMð• !>!"$" ##1 ü¢`°ÛöçŸ	.
V
©
6ÃÂ,§šÀßãëï÷ü VgÏF˜/;îVc7”Ï�èD, Ã ","·"Ä") I 	#.T¬­°³Æõ4L[ˆ=Íóö�œt�ˆ‹‡ÿQVz¦äÁÍ»åØ!û!"1 i ˆ �¾g€]r.Uÿ0Okuè»2Ï�!R‡Îná0€�øj¾6�Glò:o @„ ¤ ¼ Ì ³" ¡ 
G„|ô�²	”
+D­+=øÏ0ï< !ó!ç"# ¦ ­Öï¾Ž©)	_	 õ.4¦ÊÐå¥áñEsc}ÉP¹á‹ÔC3 f q 9Ê 5	\	¹	ä	ó	œ)–(+GÐÓçùÔ€¯Wrœk¿ÖêÇuNÃi(¢É¥– ²!»!"%"d"¿" * t jx‘ Eþ%’;ˆnÞŽ HE"\²ÌñN{œÜ# ó rD'I·Ä
“éÎØÃ*¥ñ&e!?!# — ê ÛHØ!]x6ÅøøoñxU3Þ!6  öý aº²	7{€V¹d-Dw¯âàìøýju™íYÂ-ÀÐ…ÆåBÍã- Ä �!"!"‘"¸"Ý"ô"% Œ ï£Üí÷w<	‰	/
"v²·ú0…¨›hR0<ºïdcäŠ—Ák¨ >"6 Ü&Ý±ù@…	 	ø	W
ª
×
¬ÄÓÃ"zŽª®êìÁÉäðGË ¥sW\•ü•îByÄ “‚6éá-"1"£"4 xÈ™~³èþ	›¡ÉhO®#G½Äü’¡W•Ð¬·Ïåø\®Òñ8–œ¥Ðå®\gy+õEP›!Å"+#* ôù$p®±»®¸>¥'Z	ñô�™ ŒÎåuÇl~‰W½¤¼”š¿ÂÎ¾Á•æ™!- J L Â r/13>UL´Ç“ÎÐÒÔÚx	Ã	ò
o—�Œˆ¦{M´ºà¼"¾L Ù!S"€" 3 A
ö\‰qjo	à
¡»Rñ§&¶XÁvnŒ¨ÔU"/ 
Æ@­v&5M¿	}	

L
ô
÷GYvÔñ!gŽ€(ŠÀ `œÝå¬1\	T¤I™ !ü!E"7 j ‰ ä+Ú^sÉV¼¸ÁÄÇÐä 	&	�	•	s
ðî™Æ)"SˆÏ,o‘âÆ‘·7ó;#@_ØQAP…F¥ ö ´"- N �³¹¿h�…Ñ 1•Ñ3ºØöR
Ò�‚§k§ŽHÉpÇ 0 Í -!S!j!¾!i"‚"à" ² WÎ/òPv¿ÖàéPl¼7]IÇ¤	Å	M_Ž¬©5À½ Õ "! ª §³ì¢lÚð%
L‚Z11ù¿LmŽ  0 5c…Óz	^pÞ”X µ!ô!v"è" Ä Ý HNl¶ï6}„•
@E>Þ Ößð! b ¢ · qé,Y`®ù¼$%J"÷"/ y ý t] àõ�—³	a
|
ˆ
~Ìqæp÷Ÿ5
¨,m¯ØO…ÐÛã1=¦û;= N r »"$ “ § Ðouû	N	ö§ËÑ@X[âFƒÂÅdg·Úº#â¡´öa!¸!Û!#(#) œ äðUg¿ƒ�¯ÖÜ?N*2`	
ˆTÎù5@¡¼KtLöQjÐÑD}Ç {!È!" d×¡
Ä
æ
/¦òïZŒ?}ÖêÕÖÆ¡  ø }®‡¨“ª®	�
û
j]æ“ö�~'}ÊÝâSÓX Ð2 g r �ž+ý‹ Ë]	·	ö	ü	 šŸ),fã£¬Ñß»úÕ†ZsTB¬ÀÅshÄ@&)£þSÇ bÌjî¬J
Â
—J>I�=¸½ZR“Ÿ¦— ³!¼!g"#  OQ`‹;º	Þ	ô	SHÔÙ<X�ÈÑv¡*,;f	Aj†ÑÊWÅ"&"e"1 Y } Ò CS:=—H+¡6	¼	å	k
ì
�ß*^|è@k°HlÀ×ëÊ.O˜þˆü f X!W"À"ë"0#   Lá+àø:F<:“oßV�j'y|ºYl|�Ó’ + m kƒã^‹�<‰FðC#r³ÍòpŽI�[ í!{"#!# Ê Hž’!ÿ¶ÔòRD
![oˆ•2Ê]HOfÝÇ&!’! u y^&«q	¸
â
&çY£ÔI¿ªN"# ]É(Xà	Öÿ½/”©³ê`x£8qx¿}¯²?MÖI Ò "¯"ý"# 5 ô s¿Ís€¸ÏÙ+f��'Yf! ü	JU�ÀÞüÓÅÄˆè¦®T¤Ø� ­!# <Edl�	Ñ	ì	·Ûò%AèŸÅbü
es—´•ò$ T @! A
ÜIvy=C^ŽEºó{(‰•ùpÎÕ(" ‡D§_"®¶ÿb…ù½ÌB„¶æß!
""# 	  ˜ ë Y�Ö‰]f5ry7šÆ4>¼òy«r!d!¤!é! UbÙÈŠ½Ê"'ÃV41 þ!O—Ñy|Tx·Î.E‹Ÿáíùþapv”šÂZž.¶ßï·Á  $Ë!ñ!"""<"b"Â" ·÷<a•Å	Á	
hWºeK^ÀÇ¤Î. Å ¹"Þ"õ"  B	8˜`;æAŒÃoÈ}†æ>ä� �!«!"y"6 ¡çéb»³î)	˜	
�ÜRÌx”°ã/<²ý?k±Óî@bd„Î´tµÑò C§UÂK¨ùE!©!"’"§"5 ¿ ›Ó¨¼(ORd™œŸäx-	Š	¾	Î	#s†œ4Bmœ©iÕ=dvÌ‘ÝDåèþ¶¹ÄMTl Ï!þ!G"7  # 9 � ð¤.x“½ÌîÄÍøHN
[
m
™
wd‹-û
1‚-SØ1‹â»Ý¢åVa‹².[ª› © ³ ©"ð" [ º ?ÃÝ[*
0
´
³¸#�³Ùðë:¡¦Âtz ù ?"‹"! T ëŽûY=	=	Q	EJIk²Ö©ÊYx#1ØóÐÌeŠ˜oh G!Y"q"< áÞr«úE[©	†	¡	ù	
"
X
À&[«¯ë*i~É¤}Ê>*ÌJ—×JM]–ögzÿžï‚V~ƒ¤\™þF ."¤"Ú"í"7## '¯ô²TÁ+	�	š	
v
ŽÅùBÄ#{�²=bÅ–ïI®^7ˆ»Î"/ '8EÝa7¨A¢Ê	«
Ø
ö
O­Ôì:©z–¬¹'¦Mht´» ÏÅ�ÛEŠêâ—å!2"1 Ù Èç+›á†˜í7±ÂåñHJ¡2X™ýçCvÓãô”·öPwWùÑì+Ù Ò!* _ · 	l	ƒœCLap9H9Ñàãìm„£¸ÐðB]f´:ù9—�3z=F€Q° ÷!1 yšÖð!	6
Ð
Ÿu¢¾Þ¯³Á$å¢¹øÿõ(¦tš¯]hÞëb9™µ‰ûZ!”"›"Ö"#,#2#4 @  Ô -<ÉgJ¯Íë	µE	ÊþÂóPê¾Å“X´æríU=A�ò<Dß ¦ÑHQ+©,ÂgÆ"9 U£´£œé0	8	Ú	ç	ÿ	:
î
0=d!,iTlŸý/–©­ù#n†Âæ¯FÓ0Q]græ}™œößœ!", «¼ú|ª¼¯z¦/æU
¨
5Áò+qÑéõfÎ.4T†“ö:çCº Â !<!"¶"ã"
#, H ‡ Õ-	F\q¯²ô3T<ºŽ(òõŽ¥Ï›ð DmŠþÈ¥½ÀFkÓ÷BÎ/; £ ~" p HÉ[	‘•'¶æ
V¾Â[n2 ‹ õ%wÜ}¹ì?v²š¶
!�"Cv„á‘ÈäX¹b•›ÃÏ¿[fx’ä–À § Ž!š!�"¢"ó"- K Á qÅó02?Kou%’pÏÑÓÙi¾ó
Fð Æk‰L³µ»“ß½À u‹D"T"6 M *V„²ÐÙÈ¡ñ”¾ÐÕßOÀÃÆ6\HãŒ	Ä	Q
r
Ñ˜Å(Y�0�¦¶4K?Æ×OE¿ ,!i!�"+ Ã ü s4\MkµpîßÒy	`
‡
}pž4o§Ýl®×NÝ»Ú#<Õ$“M I"u" ’ ÷ |ãTf†§‚’ÕÛ>M	œ
?|"RÒWÕáÐÚ! "" Ñ BNŠ�Ë*–Šií*ºS)e·¼@Y%ý’ûRVÄ W!V"/#% l KG�*‚ßâ÷]9;ŠªQŒp	á
%XU¢&x{”¹Geo�‘H©" 4 ¾WûTr¿ÝûkÐ	þ$¼¨~adewS€¾”œ£LÕS ü"   †Õ^uˆeqò'aˆ¼Âqµ#) ¶æ AN–Äí(	~	—	À	
—xÛQw¶Šž.‹“Á?a�Þ
=Ÿ£J#Œ !ð!"7 8 S š§-w’ú'NQX›žÂãÌG	)
M
˜
³
HcŠÕ"�›Xw�¨×uäê9U`¥çýµ¸-n y š ø ý!F"4 Ø 7Ç®ó`6æ§¡¨À	�	É	

u
õ
ø9ZhÈ6«)fæÎH­þ]�õO}~‡ë*Ñ!ä!Ù"6# ,f 	5
9
<ýò²ž¨åsÞ2G›êa8<": G o Š »,vÛE[¹È�åT
4�ñ&¤šï!*ƒÐ	eUãý3Ça…’ZewAÍ.Bÿ: ¦ ¹ Á }"µ"â"ò"6 òƒSjt…
$ð½ÏÔÞNÂÅ5[hÑâ	P
_
q
†
›
E>ïÄ'3/Q€­¥JÜÏtÖÙ’h! k Ð J�ÊÞúWý¹#Tp%¸?»$RdQ�GK´ V!û"- R +6µåM¦_•Wâ¦ §	'	Ž	–	t
²
büÇ‰-§’äã 8Fô<|`´†"÷ ï!"5#1 Q 5´º‚DR€Ý	#Ó4Z	S
^
p
…
±
î„¤âÿ>EIYdvÛsÌ-c! ¸ U!á"P O P ‘ijk†‡ˆ”Qzåæ !"2ÆÒ'deqryÙÚ]
o
„
‹~ƒ¨lXctu­®qrÈÉÊË+,KL   1 � ž « µ ¶ · .!/!T!ˆ!‰!¿!ƒ"##) ’l‰�ç×çc–ò(jszVûNŒ‚©m¨Þòûê¯FMY¬ Î 0!8!Š!j"„"# å À•Ò{3ÇUf»Ù÷Ûª	¥Ó”Œ&�Ê�‘r3  2 Ÿ 4!k!À!$# lQ×ó3O„RW©Õ/U¦N‡­ Ï #!(  â 2Šè%Ø0`¬Qm½8D=¥	Æ	ü¥ª­ßçü%0 Áéó¾ Ö í 1!9!‹!k"…"( ³ Xm�ÂÏè†¦—ž¸áê)^kt{JWÈNd`m™ó�ë kGyx “ÂódwÀT�ù�ƒÙnòª6°Z^Ž - æ ´ñ

h
Ý
¦•[½¤²A¬ø! #%#% % ; � ¨–Ó|£¿m›ÛJg¼ÚøNÜ&
Ôƒ/7ƒÚ*MôŽ  5!  mÎ4V•fy2)2òH�À'Waµ0sÙ] 3 n 6"«"" « Áù0íÈŸ�«	y×M†�½è�ýßú�nË�Ç’4°] l!�!Á! ( Ÿ 6d ^†ôÍ�	,
’
Pq…µßqÖwößci 1 ¹mØ4¸Öô$	{	“	nt‘›Û¢XªV§ Ol!y!¶! ¶
µåª-@ƒ0<P
Y Ð $!é"  > ] RÔØ	b_’S`�ˆ‡•É® Í!õ!:"`"w" ›Im1”7Rgn¾9EÇ	–
A¦èü�M¼¡Â  :!Œ!! ã 3�#OÕÛað%1B;TŠ«›Óàý<?Ù×1vñ¿ 2!†! Å ‹™!·ÓÙ#~>U	®hjî !^"  Þ é&­Q…¦	€
ýF-&ß!àêô× Ý !l"†"  c £ ´ ¼ Ç 8ÃéŠµr¹åX-eò%ÉlÌz¸ ó !K"% „ JY‘Ðñ‡˜Ÿâë*‡ê_lKßc	a�h£ú½%Hvð p!s!~!Ñ"ø" Ì §!9|-@Ì
¢5z—ô‚‹J¯&û !(!K!" n¸-€åuÉóF
ZüáOeÐa#n¯š�k±ì!çy¹—"ž"  z ^ÁŠ�˜B	W	¯	´	ð	
Qrž¿à 6O©7‡«±¹ÛÄ<¼"* ÖAßxs€2
}
‰
Œ
�
çqøú]„°í,9ó7¨([�*ü\ ÿ v!”!A"�"" þ ”¡Åeö‘]
pÍ:UP-n°Ùoˆ4_QÑä2_ž§ñ> s |  uÃýôáb
‚‘º%×�ŽÚPL.®†Ü>¸cmŒO  ” ç ívòü	ªÇ¨†­h+ã(4íâìÊ ¹!Ü!)#  . w ¨ µ}	

Þ
ä
[m÷ÌÒY\ãÃeš$¥/¢ŒÔÝù—!#&# i
~G[3„Æ¸¾»È­" b!##   Ñp­Ëé.	O	j	¾§–A\%Öû=‚;HÛ³BµTÀ÷ÏÔ"#( � ©ñ(�{ÀÓn�°×Ý(K½ÛùOŠ'
Ï´uÛR2ÑõE~¾¡ â!s". E à å÷h}À„¤œ¤ÜSbho	¨	
‚
UÕú„’¢ÿ»·L¥÷	k_Üðù(«�6!" & < � —Ô@O+ÝS	a	
½8ÎÕM+fN	þ!I!|!Ë! V{¢¯3º
‰06A0„µÌ&Ò:È É! ¯ $ë�BCÆóÎæg�Áÿzçáîq�¢o P"¬" n[W‡ƒ¢
2§bð*óI~Ö¶1<Ú7" `	s	Å
ç
Èg0Ø«z[wžÁ××t^ ƒ   eØÏ5±v†–¹üK33ž@(Xbë	Ç_¬4 b Ù ß , V ‹¯		K	>
y
ž
ü
(BGL‹é8ç”¾÷jÛézž%õ«±Ëo¡–	ÑöC n"ˆ"& ¬ ù ÂúXˆî?É„?	¬	¥
z§»³ØNŽ(+øTÔá“„î5±‰ m![" ¯©€˜�f	¼
^¯
~ŽÒþû©ãK‘#i8š]!‚!Â!  ~1ý” «5øÓ
kê‡2¼ÚóÞàûYÌ�È^ j ' 7e¡í,BJ_Ù$Œõ ž	â	-
ÂEÈ¦˜¿ÌÖ[:ìb6ÃâKÎ€” ±"ÿ"/ h   ¥ Ž¬Åþ/NZjtƒ‡çÌÎ^	“
-3ä€¤àŒQr†‡|àUyCO¬�iÌñÿ - ) e s ò i�D4	¸	›(*Òø	Õ’ÆètGÍD×÷ð'Mz›¤wTÈÛd¤* ŸÇøˆ	÷	ý	! g­­®¼Ãût¶Îìr­Á”íAx„ÅAã*ôàOj "0"Ü"" 2 @	º­·|	K
˜u}¿ð£Ü¹«¾W[SÀ!m”§½K ˜ !R"  ± ²ãÍë»Ùkï¹×õ%	”	£	$
Kí«¨"^PÔ õ !!½!h" Ÿ5Ëåoö?„âq ´! › cnt1­Ã
Í’õJ‚œÜÙiY>|é õ|Å `!z!·!Ç!+ PR_aŒ:<üGÿ«»	õ	û	RI]«Ø=YA«ÉÐ +-:<g
Q…‡žf"ê"   É à]µÓñ·
æZ‡i¾1BXkÒÆZ %!ì!M" # \Ì;Ècß	ë	¶ÕÚ@ž.Ò_w¢7Ä	­|±XH Ñ "®" ŒT™µþz„!=”&ªËAƒ
!è!'" ;”Ð_Ë“±³nsÇñÿ¦T§Ê;"a"x"¦"Á"*  " Z ¾ >˜Ë<,Z	½	Í	Z
l

j±,Al",ØË¡Ë�Ü ‰± Zsg Î!X"ï"' &Dàª*DSZ!
à%)}°I1Lag–ÖL˜Äõ³º�[‰ýº–Ø ì"4 ? ^ ~ ¶ Ó ;TI¢›Õ7	Ù	æ	Ï
í
/cž +S`ké8mÁìTô'@E¥ø/P|™Á´ˆÞ¯ Y!ö!1# † ó2;Gu”	Bpà�õ‘Zm;!�! ö p)[±ÏâJenío¿=½XkÑKÔ>;ÔŠ+!   M…œá•V8Shì:‰d(`z}»½“¢Ã 7 × ™,ùFÃÈ	—
;8šW§rtéGýNü}ž)  n Ï *Lu„MŒáDa%= P¬Î�J‘À g!î!|"ú"$ ä 4Ž“PÖÜä
bñ&YUŠí‹}áþ=DsÚEJXbq2 3!‡!"# Á$_«·2C<~ScQ˜Ô€ñTj¥$�xŸwò , lšMŽ
‚x(ñGœV`@´ó/Ø\ €!5"#  Ÿ¸]·Õó’	œ	©š,?p¡Ž	kÞhÈ9"_" Œš "ÒÔÚ“"$fS‰šÒØgi…!" ƒ Æ Ë I7‰´ä,?E
û4"d$Œ�–ÈŠ°ËI®uï ò !!'!r!Ð" ‰ €rV	�\¯38K-^­¸ÚP'�)b[þ u!“! v ¬-	i	ã
ZÆ}Õ™:GÇ.'3¿ìÜáëÓ" D ß ö'z¡®'Ran§	
�
¹
‘þº´¤^Û9½!  ê_†…¸r	ÇÅÀ€«‚ Ø Þ O" ÷J	e	x
¤
'Aè²iòJà"hƒíõB m"‡"$ d ¤ ÄAI#MYsæCá	2 ­÷—ëa“5ËÍLyvÚN "°"þ" ?ê¶º0Ê|¾¿!ƒáJ Ó ô  !  È ^9:‹þbQ×Y†ª´y½9Ã ¬{°@	!ç!L"#+ ! µ ½ :ß©Ê);YYÌ	Î
. 	i¯0f•Õó&D¤¹ ÊÛmrÆ€°À~¦³¹×Ý 6 … õ „ZÎdòìtë7™qÐ_û(*!% Î )Kt’À™ª¶LL}à�b'PO|i¤DIWŒwž !4"ù"   ‚ Ñˆã+ˆ ‹Ž™ÇÑ7‰�,¬Ù&(aZgñ ý !q!t! C  `mI	d	¹9]Úg¾‚ìA � Ò" 9¨":ýX/Í
ö–®XÔ4¸ÊÚÅK«¯à¥Ù! Í ƒc
K~|H	6˜8OŸN{^˜ÆˆŒCV'`
 € ü )!5 ‚VW}ÁÂßàýþ.AB|7{yz¶·]ƒ„…†‡ÇÈÉÙ‰Š§¨©ªçBU™ ç è #$ bŽÃáÿC£Ö}»[v|Žõ	ƒ‹é.Gè°š… � é L! !®!#* o¹æu	‚	G
¿
é
ø
s¯×î?=Ü¶)\é Ïíý6ftl±–0( U ¡!¯!˜"Ë"$ G¤.��ve¤ÊÕ	í	Ú
[¤¸Ýb¨w›"€‘ö
˜5µäèv † ê Ÿ"& Fc²ÐîôÒ	ý<âÚPfó¼Bu–$}°Ál/Héz›º% ‘ ) =Äâ Dm­
Ç
«~Ñ&J7Æuj	o�æê
c²"„×ÝŒêóã A!M!# Úpƒ	°	ñ	t°ØDPª£Z|Ð)£Š¬öþ7gm1) °!)"½" Û Îçù‚%þX	v	ù
ïRŸ>*]J�»ô²V  { ‹µ	B
H
À
ê
Ýáwz¡Ý>iFˆî–úüqº²ÏÅÓÖ=d ¢!" _ºÂ™C	@sÀJ7È9··Þê_¡!8›áíuÜ—§!™"Ì"* zˆE×¥�¨3
\•ˆÄçó·  Uc’±8¾b™û�¡+éCw  !""B"Ž" " 0HBjàwf“¥f
Û
ùcû×#-¹Ô)\ý®ç8 ë * 7/ËÖ	î	~
Š
�
�
`€ãOrœÞN^x5…�†*:ôúK¶åa…·  Û !w!" Ñy‚t�ˆ¥¹è`#;©¯œî÷dxå©R6Í]‡ •!à!#1 ™ ð ÿ ZgŽÆ×-h’³ÑïÎãŠÁ½ 6z8±Âÿ±ËÚë5B?©RYóz¨òœ»’ Å!ê! —5d»õ
QVgv—rEê`¬se!' 
   ¢G`zÓ	qþ=Û;ôHs5%�o‰5Õ½�å3}Û& ? t } á É"$ ì î •ÊÌf÷^xMš^gCQ~›.ÇÉépm0I`ÒŸ{6 !¥! �V»cïÚS�
pZdoØ–(¯‡dî8�B! éâÈæE®
¬ÒØÛ#³#…/�yÄ¹!jnP ) Ä>õ³Åã"˜c
’&³EK8év4€ƒ�‹�¾çÞÝ?W-5ä ! vþ›nÈ
ƒ'‘ÉÇL‘k Ëë0? QMëø2ÉôN!Ô!#$ • è P	þ
Ù}ElŒÜâîúÿUE•h}·‹¸8îã‚í* ù!"#"*"Ã" "ó±	*b†P/à*5n?Ë !×!ò!" qwýŸò	:‡ÏÝ®qw›ÃéÂ÷!)h±Ë¡ð%2±!º!Ý!c"¾"8 Ûîÿ˜±	;	„	Ö
u«±ÒzÈUy©¸éNcù/Fë ”Qi«Ê÷[Ÿ¤,[Ñðû¤ä­ÿ5‰Ìâ="*#+ ø=¤&	Y	n	w	Â	

ß
ñ
ðnX‹ÍÓf–ä '¥º_›¼%™0£HÓ˜! © ¦¸·ÆÿïL+^�Å¦È�/ R!ß" / a x Ü b¶èƒ–{
X]_	¥Þú:W º"ö"% Ï~®úM	

 
å
ú
i‡S\ø »?WZÁÄîKf&¶õ³ÏŸÕÏÆ #'#!  X | ¶	Ý	I
j
Á
ë
™Þžeâ{¢Þ;?Hj…G¿Är—ý?ÐÆe 
 C
9ÓnïÉq�‘!z" Œ€	ñç²pû~‡çr–³®×># Ž ¬!# XC¦@
ax<\4ÇB�D­¹‰¼É3»ÍÔåc!£!	""'  è`
gSÍJ]:;¿åü>@`o°ÒcƒÍµî´¶|ÁøD!¨!ª!"$ ¹ Òê»�c¼ÃP	DIr	É30×²ÔòŠÏáÜCÃL©S² F!p"Š"¨". qš*	™	N�¿ëA…¨—y•£±|¸&=<IIu€ÒÚâîó¶DUv£V˜øÐE Í"E ¢®Ìê´ï	/	D	k	t‚½ÝÁBKoÀ8ä.³¸ßâë÷þlƒ¢ï"Aeq…³9<œ;CP\fqŸ˜*¨Ýf˜ú“"š"Õ"#% ªÔ{©S|ëy±.§
µÀ
µCèôÍ-¸S9EjÒãö¿¢ !"�"¡"	#/ ‘ À û {ÄØ¦� o‘‘ØÞLG‹	|ÐnÅjÜ!ÖV²’µÞ3¿ÿºÅ#ND ÿ!C"H"t"( ‰œF½))Ô)©¾ÜúP‹Ï	$]t‡dw“`‡cFdü‘úp›UR #.#8 ò‘Peš�ÁåËì	¿	
(
4
8
–w‰ÚPµ±�5v�ªÖ>ÝeÍœ_šæé·¢,7;êmx ‹ Ð!ã!"Ø"5 F Iñ¥Zi”áï¥ÎÝùgŸ¦O
š
3VŒû£ Ãü&2‚¸d¦.Tü2ã`$º{³Õþ³9 "ñ"4#, æCy~ÅTcipxØ	©	\
n
ƒ
°
¤“úM
£Ýñú%éWb¬Œ�*œ ª ´ 7!  á 1Ák…¥�ƒ¤ølØVæ.]†/èì % $ : Ž ø/¾ÍžI”
g
Ü
xeÖ….6¼çÙŒü¼Þ£)±Æ\«÷¯m ª"" ' = \ ž Ì#	×	+
‘
µ
a´äms�‘´Ú_‚;võO
b†!x!Ì! ˜0AP:T	
û,;�L»uÿÜ !]"! » ð8†ä,Þòb	Ë
¡àÏyñjg¢·æ¸ ú J!o!}!–"�"* Õü@ÄÞ\A	®	ï	
1
‹
Ž
	o�P¹�¾ß$9ÖON6†‡ì+§·ðlÃ‹ { @"Œ" ì|Êè©½l…Z$2¬ú<�*S‹ÓÎÉ –!# �Òz£‰	R	/³¶ËÍÔïø%'e1ªýH!Ê!á!r" ® #œZA°u‚û1JB×ªaÍåfv�þyæàí;^pa . U WŠü >ƒ—4>	=
»
Ò
FKŠ¦º®é71Ú	y»Ù$ô*ª°Ñ÷ú¨•7™i ˆ \!Z"? ñ hÆì«�Ø÷.i‚3	‡	Á' D¬Ç‹¥Â¾Ë{Íë9xÔ‘çN«FŽÂÌáìC@Jƒðâïšó£“ /"Û"" š °  ±âžs¬¢	#
Ìäìõô~ïØhÛ{ªèŸ]ô{Ä¼p _!Æ!Q"% [ËßÇûF\´Òðªê	ú	\?˜Ïý^Ÿh6 “%W„©‚�G ë!­", %C“š	 
Y
Ï$°(+RjÊ!7+K?K—²Ãô÷ ² {Ÿð¥SZÿYr¥"î" Ö o˜(°Uˆ¼ÂWcôJsFÓ=:‰ 	X
C`$ìRw—ðUS_.af! 6\³eq‘	›	�ú3¨™+>c#J¯×·œ­t„!8"Ï" õ„·ö,	h	
w
£
@Æ±Å|�Äh³ñ˜Æ28ëÛ¼!    9>Þ@HLBaË	PÉÿh1¬{…C’¼ŸÂ¾ ‚uÜæ!  B � (©µ&\pŠÐ6«Ø‹ë~@ 3", �b8a
{G	Õ{—õ•­ºZ6NWuž�3Mxµ\ÆØ‚-FßæA_˜	 ~ „ æ Ÿ!9 F£±Ïí£t	Ô	¬
¾
Æ
Ù
è
÷
r®í;>ªÙÜ<µ(It6t•§iÀÎåé	!ÖÜ5k4ã/' u â Ê" Ú ÍÙø$ýÇ8h¶ÝI ¢Yš¢àìõûÒc ¦!/ /yiÐ6‡’e
”âN‡›_ÃæòM:4Ö
T)cwä¸JQaÓú
 `­ 7 Ú !+  í ï f–ÉË4,g_wyºL™ÀG4 œþÈÊèêAqD¨ÔX€|Ú5 à Ä!È"+ è²šœÇå!—î²DRèK€�3‚/>ŸYn•÷1xÈ ií,7Ó!* ž°	:	Õ
ý
)9èDMbøkÜêÛT“…ÉöOgèú4°Êˆ>�ïáÖ!ø!# ` ¥£­¶L	m	z
Ÿ
ð
W†îŠV•Ÿí&¤¹%^µÄ˜ÎžG9ÒQ! W W¥Ü	?
�d:ðÒC¬m±q2p•ÌŽ"C ¸ Œ
	CHMfŒê„¼nq¿I¢-2{:¾áäön¯Ññp‚‰²Ìà;Hí:BO[epžÙ{—)¢—
eR÷D ± C!o"‰"- ú Ãz€êÊFë
7
¦
{v´¿ÙO	°´Ì,ÜÕ_´†›^iâcù"6:ošQ Š ×"##-# Y�ž×¯
2£5Â%�æ£ûU¢$è°zÅ…ö²l 3# ûï…ã9ñ"	@	­	Ê
n ßl�iuŽºïk¶Šn!\"•"œ", ­ "‰›ÿ@–Éçú<
Ñ
¨¼.­ÓÙ«ºù €)äöù)§uý$0ßì”ü` [!* °ÅÊªö�™2	é	#Ëÿô'QêwÓî�ü>žªóEàI’žï$ÃX^! Õ p¶g	?_°Ãë˜"TÒR-9›ƒ!/ A € =€ ?K´°Îì
F	½
 ”´Ys”5V„BŒ‘¿Íäè2L[,4ªjÞ@.å ž!* .x3h™Æä #‘d
“¿ÆFLµÜ9ç�ÿ�Õ=	S¡§ßúh6Ã!Ç"4 V¤¢¬µ¤9	Û	Ô
ï
e…í‰Um¡,1’½õ®È$NoˆÃßçl°GìA1N~Í”�ÉËàP!Õ!"# !þ•œ8�êù
;
É
1m-k4€ªËúã¡ü^htçøõ_ k # wÿ2o1	è	>"ÿ—Û“!ÌÔ1RZS�îù3�!- ¡67 
l„ëìjˆ3 þ()*+0ÊôM‡’áâ@Rsš›œìí‘’“Ê÷O!  7†  ›GACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GCACNNNNNNGTTSAACNNNNNNGTGC,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNNNNTTYG,CRAANNNNNNGTC,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,TCGGTC,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,TTSAA,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GCTCC,GGAGC,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,CCDG,CHGG,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                        "                                                                                                                                                                                                                                                                                                                        <                                                                                                                                                      	                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                                        
                                                 +                            &         	                                    
                                  	         6   	                                                                                  !                                        
                               	                  (             
                  	      J   1            	                           
      	   	                           	      
                  "         	         '   C   1      4   6      /   4   *   "   ¹   a      *   �   Ž   (   *   *   %   r                     "                                                                                                                                                <                                                                      	                                                                                                                                                                                                          
                          
                 +          &   	            
            	   6 	                              !              
           	      (     
      	  J 1    	         
  	 	         	  
      "   	   ' C 1  4 6  / 4 * " ¹ a  * � Ž ( * * % r   �©  �  �=  �™  •{  œ…  §]@´"äBÑ` ¤ªö Û	m“êvëìkÙðÛ®ö,M±äGŒèóp°^p-Õ!ÆA»
#ÁÅéÄ
j+Âh Et WÏI=[ “mð�=›"] šqˆ
ˆ
�=ÿ»ÃÐY"ª <çŽY²ÃÄ˜	Á	
m
«
ùRW`�C
–©‚“¹ù©ã?mšÌðù]ÐÙÃ=A�ù—�ÝHtÈ}¹=Y"‹"’"›"¹"6­�QÆ�Æ�Æ�����A×	ï	‹
»
mÃbÉ ê2	êEi
1L œi ÿ#
•pEÌ]õp
�	]#	“«†}“_«#åñÓsî!Ò¬¨æ
š!ªwèæý Ø°	ã)8¨Ø 1r Ëv
Ô!v¬¨
™Ñ‘äÏÅ·ºa!á<ó§¦"Hp	©  ²5	<	ä	œ)€çâjík¿êHN—‘"„vÀœ	!¬! ˜ ­F ¶Î[­O*#lszÇM_òêâì]£u  ²€@âÅjí·ºãa!‘"(	—	(  N8Û‡bZ2Fƒ
ÆßGÔHÊåˆ f W"Êˆf W"¢$ï
‰çah£v)\ÁS¡ç6	å	ì
*§lÀÊc.ˆf W" ­
ÆçÀãïF Vå�l–!hûc  ²€âjí‘" 	r[ �D!åoöëCÆÁ^ø#ßehW¼ ²í(	—	€Ûw¯âjí?ÐB‘"ü l®× ¬¨© ²ç	5	<	ä	þ	œ)€hçâìü×jÄíÿ
k¿êHøNl“—õñ?!‘"«‹xè >{¾¸Ó7 x –:º"ê Å{zY?K£1	¦
2¨�¿dŠD�Û«ËÌnû,Mg)q‘íàu˜¡Iî#P�(8Û¯î‚» ñ·¯	8çLa÷Ûéõùçb®±ñô‰¤¿!DF[ê
À¤Ê~—+¼	@k	°!x –ú
F[÷Ÿ:Ïº"Ó\£!àÙ!u_
SÆ¡ç6	å	ì
ß*GÔ§ÀãïF HlÀÊVcå.ˆ f W"·
r!w!NY?K2�û‘uG4Ôà È"sî[ 8Ýç¤“Á		†	Ê	
6
duW«LPael¯�7áíþ#­Ìbnâ=F™òù}š]‚²9."Â"Ö"Ú"¨�d«n)qíu€< [ ´
³�NË!ü sßô�`
+l®×NÏÚ0<< M aA		¾6›(T#Aþypní{CV
 -»Zdo–(d
Æåâ«ì‹x]£è u Pš�æ·C 
$(KôZÇM_]"€ó6_¦ áî<]	¸
·,J€ã£ßóÊˆpf W"Ì_-h÷Ef»v	H
À
rVŠz³Š7½�Ô!!w!•!#Á  ÄXÿ(	Laù	wµ¢{�nHÝíeœ¢—D "Ø"l	£¸]—FÙ¢Y¢$	eœØ"ó(>${¸¾Ó7 =í �
“�Ðö1]p	·
¢¾©M"rò Íí×d»V
ô�²	+Ï0< tàa

O…Û=N Gêºve¤Ú
b"!Ó ê ô  !zÅªêö�2	¦
´¿ÿ	´Ìê,wÓ�ªEàIiâï#ë ]fšÆ!¤!ÔÚ{àÙ!Od™œä		¾	
X
¯*iÉœ4œ©*Õ=JJ–ödÌžï¤åè¶þlÏ!¤"í"­©³çè	þ	håüØV•Ï}¬øÉ®Òá7åõDU3›!Ä"9	Ô
ý
DkÛT’ÈNgçÉ�àÕ!ø!–€¥– ²!»!‚¥¹è#©¯6‡ ­©	åØ}ÉáU3Od™œä	¾	œ4œ©Õ=dÌåè¶lÏ!	
X
¯*iÉ*JJ–öžï¤þ¤"í"û@	­	nïkŠ5c…pÞíªÇ¨h+ã4)#œ9ÑB· þ—Od™œä		¾	
X
ÑyƒTx¯·*ipÉ.EHœ4œŸ©9àã*mÐÕð=ZžJ:J–ïö9dÌ�žïz¤åè¶þQlË° Ï!<"¤"í"zÅªêö�2	9	¦
Ô
ý
´¿ÿ	D´kÛT’ÌÈê,NgwÓç�ªEàIiâïÉ�àÕ!ø!#?ÃÝ[0
¸#ë¦Âz ?"‹"Ó^”ô!v"ëCÆæ�Ááî¢_†cùošQ #-#„ó!ç"ü�¹$Ö·l‹y”‡ÃæòTaú  ¬~ïÛª¼Q"¬î½�¨	ÿ
ôÉ¸ŠÈÊV (vÓü(½ÛùOŠ>
†­«Î(oE~�¹!Ü!¬" y¬”C`‡$~ÃæòïpÛTªaú ¼f!Q"‰œ))dü‘úU.#® #œABÍåfþyæàípÐoN	@Ú´ö:#B`;AŒä"em¡,1½õ®oˆßGìAN~O|‹áíùþ”¶·"""Â"d×·òv¿YŽñ®&?©ê5ÁÆÏúM	@
?WZx<ÁÄBf�D¶¹³ÍÔ#'#™ ÿ z×¥�°	VãÄ )ÚU±©¾móz8C»Å!B" °Îì
½
 ´s”¿Íäè4j.‰ +Ú¸Çäð™)ÏâÆ‘@A¥ ´"ç›í±J2”öwì+Ò!	¬4Lö�ÿäû!+ bk�¬Â
¸I�"®=FÙ³òf�ÌŸ[ ß!##s¼ÁÄÐ 	îØ¢Ó	q=Û;Hs5Õ3& t á É"ñ&Ád×?êÆb¬Â
I�"®=ÌŸß!#·òv¿YŽ®©5· þ—ÑyƒTx·p.EHŸ9àãmÐðZž:ï9�zQË° <"® #‰œœ)A)BÍåfþdyæàíü‘úUp.#Ø¸Öô$	“	ª§O.ÊÕ	í	Ýw€µäòÊ cïp� è`
gSÍJ]:;¿åü>@`o°ÒcƒÍµî´¶|ÁøD!¨!ª!"¸ Œ
	CHMfŒê„¼nq¿I¢-2{:¾áäön¯Ññp‚‰²Ìà;Hí:BO[epžÙ{—)¢—
eR÷D ± C!o"‰"þ!O—Ñy|Tx·Î.E‹Ÿáíùþapv”šÂZž.¶ßï·Á  $Ë!ñ!"""<"b"Â"u y^&«q	¸
â
&çY£ÔI¿ªN"Ø 7Ç®ó`6æ§¡¨À	�	É	

u
õ
ø9ZhÈ6«)fæÎH­þ]�õO}~‡ë*Ñ!ä!Ù"6#¡çéb»³î)	˜	
�ÜRÌx”°ã/<²ý?k±Óî@bd„Î´tµÑò C§UÂK¨ùE!©!"’"§"Ö o˜(°Uˆ¼ÂWcôJsFÓ=:‰y ý t] àõ�—³	a
|
ˆ
~Ìqæp÷Ÿ5
¨,m¯ØO…ÐÛã1=¦û;= N r »"xÈ™~³èþ	›¡ÉhO®#G½Äü’¡W•Ð¬·Ïåø\®Òñ8–œ¥Ðå®\gy+õEP›!Å"+#ž°	:	Õ
ý
)9èDMbøkÜêÛT“…ÉöOgèú4°Êˆ>�ïáÖ!ø!' = \ ž Ì#	×	+
‘
µ
a´äms�‘´Ú_‚;võO
b†!x!Ì!Ø ,7ÇÜ&x®ÈÝó`™6f~±æù§@³¡¨Àè	 	…	�	 	É	ø	þ	

5
9
W
u
ª
×
õ
<¬ÄÓø9›¡ÃÉý"ZhzŽª®êòOh®²È#Gž½Äìü6’¡«ÁÉäðW•¨Ð)G¬·ËÏåø\ ¥ås®W\•Òñü8fs•ÞæîÎBHy–œ¥­ÄÐåþ2G]�® \gy“õO}‚›ê+6a~éõ8<E‡áë*P›!Ñ!ä!"-"1"£"Å"Ù"+#6# ' = \ ž Œ˜šŸ "¸ÒÔÚ]“"$0fAP·Õó:SÌ#	T	’	œ	×	+

‘
µ
a´äms�©‘š´Ú,?_p‰¡‚šÒ;vŽõû,;O�ØL	gik»Þ
bhu†ÈÿÜ !!x!…!Ì!9"]"_"i
~G[3„Æ¸¾»È­" b!# " Z ¾ >˜Ë<,Z	½	Í	Z
l

j±,Al",ØË¡Ë�Ü ‰± Zsg Î!X"ï"ú °ÃzÅÊª€êö�ÊžF™°ë	2	:	é	
7
¦
Õ
ý
){#v´¿ËÙÿ9Oèô	'DMQb°´økÜêÛT“Ì…Éêö,OgwÓèî�ü>žªÜóúEÕà_´4I†’›^ižâï$°ÊcˆÃù"6:>Xo�šïáQ Š ^!Ö!ø!×"##-#ñ hªÔ{©Æì«S|�Øë÷.i‚y±.ž°	3	:	‡	§
Õ
ý
)Á'µÀ 9D¬Çè
DMbµøk‹¥ÂÜêC¾ËÛèôT“Í{…ÉÍëö-9OgxÔè‘¸çNS«úFŽÂÌáìC@4J9EjƒÒãð°Êâïöˆšó>�¿ï£á“ ¢ !Ö!ø!"/"�"¡"Û"	#³ Xm�ÂÏè†¦—ž¸áê)^kt{JWÈNd`m™ó�ë kGyx.x3h™Æä #‘d
“¿ÆFLµÜ9ç�ÿ�Õ=	S¡§ßúh6Ã!Ç"ôù$p®±»®¸>¥'Z	ñô�™ ŒÎåuÇl~‰W½¤¼”š¿ÂÎ¾Á•æ™!Î )Kt’À™ª¶LL}à�b'PO|i¤DIWŒwž !4"ù"p Ø 7¯Ç®ó`©6æ€§H˜É�¡¨À	[	f	�	É	

i
u
¼
õ
ø9^‘•¯'Z~h¶Èæ
6G[«
3„Æ)V~Ž¸¾Òþ¾û©»ÈãKfæÎH­þ]‘�Âõ#O[n}i~8š‡­ë*" ]!b!‚!Â!Ñ!ä!Ù"#6#Û Îçù‚%þX	v	ù
ïRŸ>*]J�»ô²V   ò     Hý7zXZ  æÖ´F !   t/å£àƒ] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*jÀÎBJ„†–ÐAÝ>¡f"ôÞAv›«ƒ�Ó’©·p”ôâ&sà{3ÌT¾h$Ž¤¾hâ|=¡ÿÌß27­|r6�
Í½;29Á´SçNÙøx*Âèƒmíœq½:œðÕM‘Ò�-Œ©76)_g®†+úTSøõT…~À6nœÃá]JÔHbG>Ý7ô@Ÿ"½Í‹rÏ~Ö�ð‘Tƒ¬�·�l‹Cšrkª,™ä�2–G–ë-P8m4‹ ý•dOh¢×›TºŽ^tñqNBQëÙÃŒSTµ‰9ŸŠœ÷     ‡Àñçbh ¢„  ßÔ±‰±Ägû    YZ  
œý7zXZ  æÖ´F !   t/å£à5œ
Y] €3D]Ñ.¼?I¬×*Ó™_Áˆ½Ã.ÐüZÕþv—ÑœP´,ãVj,ËÞª~mC<ê�Ò‘Ü?vê˜dŠÌÉ;õ!U''yÍþzYlÜß.°vU[QecÕ <LýÕ3õcGÆæq~=ØùX?r+Ó<õ­ÉµÓÜØ¿ÄŠG]1”|=t‚¿´y?ç�iz“d@òP†pàš˜¨ý_CÍû}^†�0’RŽ”Éê²6K¼¢Àõ˜ ,Ör#ZL"ëâaßÅ§æÁPVþÏÇÏ¯_LƒÚˆ®y”xÎÁÂÖÁEdå{b¶F“nÒºý™8ŠÎ1Q-�‹mQÁEÐc•qcƒz�~à]Ü~Á	vy‡?ºŒ	éÖPw4W\#:‡_°0qêþ"°ÐagÏmnM�è�s#gÚÒfDÅçYðÆsú]†.üÆWwß8f¼ñ±÷']¦0Ad:³=÷�ªKïÝ4ÉJeA«aŸÑ*l½÷x1@ÚFíŠµ5ªž�Å;›˜Ëø ö“ŽF1íFœTI¶�0¸�;Ê	pô‰ÕÓ˜(iO�V?lg¨wÄNrÑdú Z–fYº,ïý•H*ñ®È¶»5*Rbv)šþvüeÊ³
-BŸ­t.p_yéÚv@y}DM %�W~|<�·oéMcüÐõÀNðˆ)å_1�ZÕ­øÓX>R°È@®³NŽÎ4xpçõ6p‹Üš<k»	E
ËØqÝ¹Gð0²"éòë—á"aab"D¨<ˆÞë:«É
ë¢gs†ÔË7‚óx?‚‹O_ `¯º«	0�÷²5	ýIÏãÞi�ë7ê°óì·8¶mTóŠ%YNTÇx‡—Ùaa'øÒ>¼éÉ45š³êÜ.ÕÜÖ0?h¿ðé3f#Gïù�­Î*Z[~»½-º6ãz!ø–kfcé(_ã¹U8&¹ñ\0Ü.†1Â 5¼ªV7¶´¸³§ß¥]{»åÂÜ ßÑ¿ƒèý²QM×3uHy¶_xTøÜO´4hŽÏÄ©Cßyµ§‰AÚ¹÷õU©L†Ú¹Ÿ£8„á|‚E¨×¥ÕœÕÿ=w9Œ0#?…PÎ�e�2ÚGNÁÍ­ß9¦¾˜M,�÷}èÁõúwÅ)¸‘Ñ¤=|0k–xè=ø2�mP™à_óáõõA)ÌÆÊ5¬Â!¡h��¬(ý`/Ø¬;ŽÔÞ^±ÎÔ»bÃÇF&|xÐz_"óæîÝNèTšHè!‰ßlŽr¯ò‹+­éÔœÑ8>U‹ò™iå©ÀÝ>v4"~ê·[ôü£x]ìn?ˆ¬ÎQlI½{/&YU¨fH	|{1Õà %ËvãPã~cDf©]>ÏbŒ%¥á¯Õ–ØžnVÃ� ßäïâŠA”·¤Ùä¬Ï«?ˆµ)Sµ¶X–à1ƒÍÜŸ,o2¹÷¦z§<Œ£=ëH¨4-•£Yñ2ÑŽIù4Ñ*T}ŸáÊâ>q<p‚L(~dèdÛ²ÍuæUk1Ð”_“K¨žm± tkÏ€Æ­´BÏ¥kÏ©‚^q*fâÿc@­`|sÿ­î·’<‚õïÝÊMëV*€–]Ø-á(BE’/—Öä=éöY�(´ô<J¡Öæv¯4¹ÝjQÄh–ÇB–D¸ Ù’UÏ¡6"éÍâ@ûÌš/,þÊqœ=¡xÂw|öŒ‹»Çá¸z¤Ÿm–SœàG’VùtØ1I·ˆáU£­@r‘=ãÃÖ‘?=é*g/ª áíÃÿGìª¡Yöy·cÛÛ¿'ú`>ÂsnZß�sôuÌ7Š‚ß¦$*jÍ´K˜lpÃ2í‰^¾DÓ.3œ—í¬“"z5:6(h/›k¥”$?£^Q‚0â;©»0_’^Œ6o<HÑ‡Ågˆ­2b›È¡D•–7jêÞTF¦Â¯ËöAôWÓ–(5]‰¬§ÅÓãƒëcÑ×ß
Ë02É³ß8t§;“Îk/ÝŸž	£>¾ëL¾¤]XSÆt¯x/ü‰¹¾bqç|Ý¢j�w´ÇvÿAì'äÞDw1d!Ê~ ÷m½ÃE¹Ýà†@êª½¶�m:˜÷æ€dç¦åw¶ñ;¿0FýxìN5Nîa�ÕYc³[¨"óËrqÙ^c_yƒuYÆø{©�ˆÔ}Ð�³çy˜©O$#H•µ%UPmùR…”[¾uçËÓ‚Uq´.u<G!þT]F5èíƒg˜½Š`ü ”–�ë[’ö”Ï­0sŠ]} zw-æ©ëµ¶ëœó²kÿŸÏ±Ã+|xµ°i°D’ù½†ˆœùÍÙãGã2$©§e)m‡‹™k°Æ4 pº°#aÝR|Q©=íÏæ0¾6'…u‡?Aµ6ÆZÊ�áÉµ÷ûk!�ö=2rßþ¯é.«…“AYÂñ·]»ôöúŠ Û7m‰^AŒ,Wëk,óÏH”7‰²Ûæ)ÞÌÿ9¹j“Òx&…-qÉ#„böÈ8©sO¾­“1ÅfkÝ1Qƒ·nÆó]�›Go�9¼*P�©yLE¿¬Iå
Æ²ƒ�Î#:’ hd<­1em\‡-\+Õ­ìÂÊžRžäigS‰/øÅPLA-þÍ¦±”Çû�KÃéŸ+õ®×]òËÄêëõÑ†t@ÅDTæ–›ðj8± ~Kv‹½ÌyÛ/„¼!Fª×QËó\…\ˆ�/Ãš,Lš”ñób’WB?å¢`®h`ûËgT3g\…zV›™ù:­¹Ü#É6ù@ÏA´Ãnõ6ƒÍ‚W¢w:* V?9Îë[0=õcÃ=ž»®{ÓféÑ)ÓXdÆîv&”Éoó$fV˜.” )c2”ä»Õ€É|¹8^Ô}ª$’éÈJmL]˜|üc<Ä¥WŽ†&åUŠv45På‘×<5>7ß'xœjìÞ�=ToTDŠ_Ìñ¶óš7¿ìð��P¹ˆmÔÇÍQ¢Üc�èv|o½l8±5ì6µ F·ôûEkÎØŸ� -á®¼[f[ÀI•VÉÙ3¹:X˜Â™š3öÓ–.Y:::ˆ’W¼«3ÏŸ9ÑÊ×�A�ðÒ³†Eþì”L(©c:Ÿ´ÜŸEŽ‡ôxCKáØ¹omA~’|©s5A
•Ý‚c¸@¼«ø5&Æ�: ší)¨7é«›»Ñ6*>È4ífá3ôg8#g²­x‡—^ üXÉhÃÛ¸ÖÍf.¿ã‚p¼F®´ï–sº¤­âJa-@´²èóZW.�qaŠ"ÿJÜ�}âcÂJ×h8¿hÍw+Âœ©¼ø8üµ?¼2ã�YÛR/@‘‚Ô´r
#XÙ¦1 ÑÏÎ§FÂ°ô’„‹,*Aþ³¼,[é|ÿ6?™w»Q·Ú”�ûf†]z7ZôÂ,e(•Q˜ëBZÝõ~SÎç[‚Uº‚(OSé¨!®¾ºCËˆ©y6Âû(YýÑ`Tì¹è[C�´6–2%æ­Á'šmpzb^¨Æ°Ò    ŒnÕ·ø9f õ�k  �pÂ±Ägû    YZ  =º      	5  $i        $is"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕZÕj›ä”Œlïü´œúâa]*¯½Ï®&ÒªûÜúâa]*¯½Ï®&ÒªûìAÚ¡ßý–j¯E¥ÒehÛº+Q+ù·»©mç·I~×¾?S­N!ðÏžäNLZØcÕ]¥Ó=®{p<14ãuOaLç?‚?öÏ©ñÍÙ±§ç<Ië„ÊÃƒE9…3˜u}°l‚#LE“£Jëcò(þ+l" ÿN\vç\LÄã…Ó`6ÓÓ÷Ë&²QP8ÕFû\�TSŸgUm¶MGÇŸ@ëÕ6'~²¿j=ü:×që#ñ¬|UöÏá¶I Ò|?P2OçÍó|è‹Æ´¶?1ÿn°×Ñ¶ÿó›í2ö­÷°Ø­÷8zŒ:°,ŽØŸ:ÄNk£4èÔy”k[�ã‚?wš“®³”MîÛIÇå5èÜFÏL0ó´Ô�„<ƒÕÎ½ùô6óÐ9ÃáÑ]}3Úá·ÿÇSàÍ$5#úëå z|%à"Ó0Äâ2òöa0ç)uÿçW;¶ÇPpàãtÃ³ç€qzël�ðáDømYÔ}	?ÓÅàDÛã�wývëð<>?q�N?<ÒË#�w	WØ|El�æ ôô)×ÏQN3"ˆ¬�Ä#åAáðÔ sóQ¼Äk¶”=EFÏ"“8@Ñ.¹v0‡ Aü?¯öM@Ä¶Õ¶3­B3`@ïap÷±1<ÿœ@ßÑóÔáBP0ÿãúÏ€vø¿ý+bpïPÉÈSÏ¿Æ�E8¾¿Äµ 2^±.|‡ôûøÐpÜá¹Ô!F3õëÿñÃü–4QGØ½ñ3âó28P1ßCøS…=çà�+Qöç`õü�xü9çœ�ßS�Û~ý×yßl�tœLï<÷ßŠø`ß7ÂL4ïóï¼A×]ƒËmQ+c:Ô#6öq+±1ÏùÄý=N!õþ?¬øo‹ÿÒ¶'õœ…7üñÛüiÔS‹ëü@ëR3!…ëpÂà‡ÈAï¿�Î�Bc0ß^¿ÿ?ÉcE}€àûß>'ÿ1Ã#…½ô?…8PpÃÞ~µnvQOÈ×�ÃžyÈõ8·ïÝq�öÈIÄÎñÏ}ø¯‰Ã`q8�IKm~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ VÛ/«è8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ë>³ûGÁ»ú€óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N       $h  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  1p<?xml version="1.0"?><Features nextValidID="25"><Feature recentID="24" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5886" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="5812" maxFusedRunOn="5812" detectionMode="exactProteinMatch"><Segment range="5887-5898" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="23" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9296-9312" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6720-6736" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6696-6712" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6789-6810" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="NFAT binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2056-2085" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;NFAT binding site from the human interleukin 2 (IL-2) gene (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot;&gt;Mattila et al., 1990&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;NFAT transcription factor&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="NFAT binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2026-2055" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;NFAT binding site from the human interleukin 2 (IL-2) gene (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot;&gt;Mattila et al., 1990&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;NFAT transcription factor&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="NFAT binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1996-2025" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;NFAT binding site from the human interleukin 2 (IL-2) gene (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot;&gt;Mattila et al., 1990&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;NFAT transcription factor&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="NFAT binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1966-1995" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;NFAT binding site from the human interleukin 2 (IL-2) gene (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot;&gt;Mattila et al., 1990&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;NFAT transcription factor&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="6744-6750" color="#ffffff" type="standard"/><Segment range="6751-6768" color="#ffffff" type="standard"/><Segment name="-35" range="6769-6774" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="T2A" directionality="1" translationMW="1830.01" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3966" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="139" maxRunOn="5409" maxFusedRunOn="5409" detectionMode="exactProteinMatch"><Segment range="3916-3969" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;2A peptide from&amp;nbsp;&lt;i&gt;Thosea asigna&lt;/i&gt; virus capsid protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Eukaryotic ribosomes fail to insert a peptide bond between the Gly and Pro residues, yielding separate polypeptides.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="13" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8718-8822" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="minimal IL-2 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2093-2206" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;minimal promoter from the human interleukin-2 gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="label"><V text="IL-2 promoter"/></Q></Feature><Feature recentID="11" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6383-6504" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6523-6658" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6078-6311" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7098-7686" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="3" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5416-6004" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8648" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7857-8648" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8649-8717" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="1" name="tdTomato" directionality="1" translationMW="54196.56" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3979-5409" color="#ff0000" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;tandem dimeric (pseudo-monomeric) derivative of DsRed (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="0" name="luciferase" directionality="1" translationMW="60645.64" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="5409" maxFusedRunOn="5409"><Segment range="2254-3903" color="#ffcc00" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;synthetic &lt;i&gt;luc2&lt;/i&gt; version of the luciferase gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>6893814a-383a-4505-9813-f00452ede298</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="1:2:39">2018.12.21</Created>
<LastModified UTC="0:23:23">2023.1.6</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Ê     Dý7zXZ  æÖ´F !   t/å£à] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*jÀÎBJ„†–ÐAÝ>¡f"ôÞAv›«ƒ�Ó’©·p”ôâ&sà{3ÌT¾h$Ž¤¾hâ|=¡ÿÌß27­|r6�
Í½;29Á´SçNÙøx*Âèƒmíœq½:œðÕM‘Ò�-Œ©76)_g®†+úTSøõT…~À6nœÃá]JÔHbG>Ý7ô@§$�/7_Øìúôè#ï¾¨¬d}=ÿ©þ§Þ=B“!èÝÂ]ÛÚ»–E-š“+ñV{_¿Auš[†:Ÿ¦îÐNŽVkí“B5Ô  ˜PféÇA,þ  †  h×²o±Ägû    YZ   ç       Þ          „Rë—croÃúð_`„ÔA8­ð#öø,NrWu+L‹Ã1÷çNáJÛ�÷ÃS�Èþßì‡ßáùÃ#HëO9ÿvÓqë­KÏcñCœ½Íöë­AÇyÔ3Ä!JÄwø!|Û…lzÔp×o€7S�'^uÓÝræmƒÇSEµ^µÏuÛpÓ#NÏyôÑwÿl1ÃüŽ8üu÷Ÿ„ßÒóøMQÿ\E3vã�+!óÏ·»�Äâu        ?  Œý7zXZ  æÖ´F !   t/å£à<J] €3D]Ñ.¼?I¬×*Ó™_Áˆ½Ã.ÐüZÕþv—ÑœP´,ãVj,ËÞª~mC<ê�Ò‘Ü?vê˜dŠÌÉ;õ!U''yÍþzYlÜß.°vU[QecÕ <LýÕ3õcGÆæq~=ØùX?r+Ó<õ­ÉµÓÜØ¿ÄŠG]1”|=t‚¿´y?ç�iz“d@òP†pàš˜¨ý<e{\î,×…ívÎz@ðÕ&ÍF×
žçÒBÅø_±–?¤K&"M7Áº<)4Ôî�ÄB�²QÃÜ•Æâí_™ñJ­Ï$5n†ç†i}N8û�Æô×”èç+ºT3rzm²0l.n�ê¡¬6Õl1ÈZ¦{™M©ÆJÐÖû¤´n^ô¾ª¦hIj~sÕ	YØhäBMêŠpÔ¼'äÅûÈ¡>»—¢1ÄÔVMg‹Gºn³„¦�K’`:Ìºª|–Q.h½­«(Ø…©vsÆItá®¤ƒ®Î¤ÑU'y†C³	Á¨MÚÞ›j}Jœ¥q&Ç&':¨¬�lðŽ¯^™åt�‰Ñûì‰Š‡�"W{îq þƒ±ðVÎkVOQB›ó^*±¥×rÖÛ`Ç´Žm½›ë§Z€6S{p¦ë ([a•…ŽAíMÜ–:~ñœr¢„GÏ$–O§Æàå’AÃ7ú†g 
/ÇÞxÙüÝª3ž`SÆž¢zÙŠa�™ÉîÐ=üÇøþº¶Š>5R7–|æ‹ÛµÂ@I¨ŽßTñî¬î‹3ã9øÆ#È7ÜÛº%WU5„ig¯Éum#Ë© ¾/!ã>ú†û—•ÿ„ú[éÈi
GîâÖ,Þ™®‚»‘¦?$}5…Š~6áÞS&ê Fïjá¦™¡VÈ8Eg¬úŽý¼»“x1 Pi‹ ·ÚÀ=7ÖX‰Ä]Näþ£ó‡$yc$$X‹©ó£cdeýåT²„®ù¶öxÅ±4RšSGœ«ÿš¢ï?ù¼Ý¼Ñ_þj†€F¯rƒÈýÖs =7’ZØóÂT)°C|p%•<%#Y:¸ÇÄDdøpï«­­@†)…Cû¦œ¯LÒpù|ùv�¿Ï¤aFöá±Hîƒ™¢û"û>WÌ¹Œ�
©«-Çt´Ø[3é	³Tä¾LWCãS}çðD‡÷<Ø|÷S¶U®7dr�íNa«ôÓx/�£_QMä$¿Jð*1Š¸é3¬]§F;Ýó‚|QÃA¶sùyœÞ§.œw]ã÷Ü€˜šÞŒÕ$¼]ëÙxÐ7'º0-J-	6ûçæfŸÿ�S¹»�œ-{JQJú‡Ø©¢"K´J‹_oŸç xêÚž@&aB,­5 �5L´)À
î§èWÎ·0z¥…�ÉŽŸ"`[7óH°áöc‡ß"Ùj�Dæ<(…dÏ ¤ˆ+õ…M„J¥à ûù]><#!ÇPWdšƒ7ºév˜Ö…ÓD2#žÂ0áÀxãN«Ë8€õtˆ:vöžºXq BˆÊ—ë”mü©[Xé°k�5«¬7À-V 4'ñà5èÙ¶òÎAs¯8èÀfÐú²Á�[‘¸‰0ˆï‘±³cÅµ9ørûó-‚ih6¨xÕ&Ú¡à#w:�wìõÚpËÕ�ïg?ÃW+&WxëÖGë:þd#m<§çzúŸãÌôwuy4{á‚ G5"dPšëÀ#6Æ¢SƒWúµHã:øâ|ð¨ÃÁª,$zžô¯£ÐøÚåoÕ Ì•O�¢HFè¬¾C•ÂY~™-ºÆŠ3ª�óðgü\ÂEVaëÚ¨Ç-7À×ûwçÅeé8IdÖ‚Oö@ySê]E\ùzÿ'—áãøÐœô
‡âÇù,!	™.ÁŽÞZlc
I#¦!îYœùŸ¤“@çÀXê_XÁ0ÀT4¦¹•:ûFç×%òA„s°g:åE.Iq²­j{Ëú¶$8@LÙ±ß½ �ÀÑ¥65€¿°	åqQ›Ñ11%@ÑPØÿã„«èNàwó‹Ü†ôÀr€‘Êór¸ü¯?wr¶·1'÷Ñ·BÚFÃ§ÿ†@p(m8�42þ�ó#7+Xàš".ÄËçÝ¤d7kþ74¬­>uÀ±áªŒ6	ÉPá#
½Òî×õ·Mpá=åÞ=Ã›/P n«¾ly³¹*m3úðC%éf@»1ø³µ›º7R¢ä¿%~G•1É x®‰B	¾y›»"Ïß¼åLÕÝxé§�þ>\$0¾~½ñÐ„êwgfU€wK6ÿÅá­n—D’— þ~Åô½�þæ¾‚oÇIW_@˜æ‚›ò«§Ë#Õœ!Ö(ìñ'Ü‰<ÈüYžªWo¶º	ò*ÄS‹áˆ5íâ·è…cÂ Ò¯ �³ü{„òä4ih…›…»ƒNG]ýŒØj›×
…“d”ÃÆ"‹–*‘Ìöž9w¹j…%v4Y wñ'Hº	¿ÔÔh}ò�Æ´³˜û’(eN}Ã^ÐCW=nž«(O{ÈA^á6åÓ‘•�¿¿«‰t-¦ýQÔï0)Aã¤rí!¡ÒÈØk—2§¤NC2ÀÔ‚=¯ˆˆ´8þ¯îUsÙÓp/ð,o@Zæ^Ù2€ñAÌ"ÈÍÑ	Iþ2‘ë»¿Äâ`ýæ9o,A‹ð €)“#Üi¼?Ú
öûMI…�R�%Áñ^ÖGò?ž(Ìà1/®«Ñ ÷ýÞ€\Ôâ+p2¸ˆý,Ñ€ºë7@ˆŽ¼3·dc~væPùoglôÛú·”ÿQ‡–lïp]¥RjQJÕÏ§ÎìRY5 [†©fÉ%#rô¤žb#å¶Ýe±1{”Ç©·Œó¾‚ 2-ØKåI�emÒ5Œ<�ŒÄÜg�»HdBv¬ZŒ�¢„ZqÒ>XM×Dú×¤ëù_ŒƒÁöS_Ãu€AæW¨Ú»çÎÓÿëSXQ¤ �7h,ØM{ «â,d5 |•¥„FÇaÏlé»p=øÑÔ‰t6î›G�Xªç¥Œß> x�Ùògâ*'ãAñ›Yâ”ü~U¦Œ�“›0üŠbì¨!cŸpçPÄ>L¶‘Ý±½åh@‹‘%»/ÅVP×i QêM~òõ�ËY|‰,õ?	§yL’äuè’cš�ÐÏš�XûÁÑ
æ‹Ç£©†S¤§Úþ­l¹àZÁØ¦ïõRP°MóÔ,[P”QŠ³®S#U´¹�ì$	%G¾¦LaÝ°ë^¡„�Ä�³^0%u’î(¶ÿ DÄ½¨åõ˜mºÓò1ª-D0r†÷©5ÅE™ãŠÃvÝxŠå’Q|:–Ožµ\¶€žÃ“MZšP«MÞõÞØkæ‡�ìN¶ÁÞ9PïÇo-êjºÈ_¸PçºLn–š ^a4>'Žy9vãô]àÿ¹EL+gwÌ@Ã1sO½bšÓ�s³‚–|.Å3q ûo?š•y±“ý>�zoš1 zc)”w&GÙz�E±*T]ï¬üÆ¨{¬ïÌ± !î¶+4ÄýÜÙvåðÛÆ²}‘âx¥Ë·áÇ[	»¤ÄëÖ”™eºæv1¤ÏŸ†Ôm<�ß<»æÅÑä‡Êà×$½üø†ˆ×·}sˆéPYmóû»5†&.¢m¤½í¾/ÀùŠk’VZàHÃt@£†ÚöèËLŠ
]Ã±—�ƒ™wBfû—y<€&¼s¬“­Ñ¶˜£ê†ííúÌ*·RÍGÁfË'€ô5óñ×¨j½ÌU?+ÊŒ»Ev}ý!S-hÆdÔÔ(5œ¸øÍB‘#òkÃ®4OY• î7A\OÀ   ÀÐVß ôyk æ—x  •®�–±Ägû    YZ  Ôý7zXZ  æÖ´F !   t/å£à—Ž’] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnãýJ„ò4@QÍ–gÊço:r-ææ”DS_ì”Ï´Op:€pì`3¿LÏ¶Å»rÿÔï0ðí[Á›n%`ôf*í¥KÌ«KÕ@EÒý"­ÛÖ~:§jÏå¦–å~úç±c^/	IŸY[ß4°ýüìçÏ)ŒAkªàF"#K¦á“¿ÀŠ¡ÎG¾3¢Ö
{­�mÓ!ñ�ÎÕ±ÀZš8ª—J'ˆur b ºC‚ÚsúüÛÌÆ�î3\¤Îÿ3öÕ}uqŠ„’ÕùÚrÀ1M÷ü4
"TœÊ½˜¡K]Q#Â�3+FÝ•¾€EŠ�ÂÎœÚ„©*ïƒ,=œzr*¤¤7½ƒP®JÛÁ¼ª¿s—Ì1G-_½6• õe‰ô o\›,9Xí¹ä¨ÓšSÀœ:Ú‡}öœæ#2NŽ<šÊc—Ð¶û'ÎvË¢3�Ró=Fg-ù,õ´ñÕó7=uŒäÊ‚´'xõ4¼wŒh¢`úÈ0¢Ö•]9ÈÌ?SaÐŽÞecDÜdrÛ_ƒdÚ5Æd>³×  ¹C"(Šq8ôïE*ê�#\&«ß9¤÷\V{
,s*QÐ{ÉŽÀŽ(÷	gùJGŒe�@u®‰?oêÑ”bä&žHdènãeVGŸÝ5üW}Á)Ê˜|2Êó›¢œÄ‡zAMhß*µŒãCˆàý}Þ¤‰ þB§êïÐ \L’Ó“V‚>vºOSµqØoßñkÒ½¯^‰ÙÜ…ß||”_uj%íe™ê!­ÔP;z6Oy	ï–ûy„,óðP5Ü†ýç"èÛØ‰×ñaÌ›"k®Q²l9Z™Ø†ø·Ì3ø¥Š­7E?†MÉÂ/„hpP˜¤šoÃ–ýKñh}øhÐy¿xùTµ;“¿uÞ^­uJ4	DÔ,†Ûìƒ$äí1s;´zqÉß~Jº�“ƒÔ¨Ò‡�¡¬ØD$0\–lòêzß*ÛK
¹m¤meÊ‚žËÍLÅ™�\)_ñóNÿ&­„SVm´È’�ÉDIÜ+5ê°cEwYè“@Ö
ÔÕî>…T;N’ìƒ’µþ†Ð+vòIÖÍÇ}sõrøôáÔ<R j~>l[ÆªJñkï4Öd¥TÀÔøbu9îrásSƒ7BÙTöSDÍÚ<öè=ëÀiH	9;)9•Qö{ºÑ–d0é(hÿ§	‘]Ð„1s£Æbó·«h<?IÀH˜8Ç.C“pÈ6’NÀ7vF0¡õh…XJ`+•êÕ�–U½¹Î-jÚl°OGªaã`ˆ»Ä8[ÀFŠ¹„º¨¸r÷ƒ<W—ú{kH[3è¼K&ki€£Ó®Œt#PÍ˜Ì™ÇÕ>ÕT'»<ƒŽ’‹¿M”°%�«sNè@ˆgù\¢Ù½±�?u¾÷3HÏbB˜nþP;.!µ>”’ñ¥&oø:€^3ÆÊº«²£Ø�ÄTÓÙ°}/ò:æŒÊ,fì0Áz´¤\wµµµ)¶Ò½×è6ˆHQXS�ë)é›ÍtL q·p}˜þ´Î.¼æ¯½4itVì+@$f—F’¿o½ÐÔÔË5 �qØ¬ÛìúkµÕÏØb\¿m@†C$ÇD¡N}_0¼[=Pm0ªa ùüno{–RÀ0��6õÏ À­áËv©…Åö‘(:VÙ`;+°³|'xVÕ+=ì88ŸÃL–«ÑR›�ÜYãE¬Ä:TªÊúr&·«›S2ç}PÿLïé¤j£¤ÞUhy»ú�/tø?}èùÖ²úÒ<Ö¯ôƒ� ßÊôY¼ý­3«—µüc‚§f`&žc5ÅÈ¨cbî‰Gì;šæ$À©Æ¸`)ÈsŸ½V7±(©^}ï^¡?WP„-}ªÏÎº)‘7=½ìÆh0…ˆ54ûóç´kÔhL]z��sí›~ÕŒ,0zí‡àfýT‘©]\¹Dà/mñfóÈ7‰9>i·�TÇTèñ|_Jõ¥¶aï,øÝ{j<SÃr…�ù)â[INzy9†£Í=:#/xÁœ”³ù@ËÍùä'÷bbO|Êˆ’›°ˆE˜­ä|€ƒæÄô.eê7Špsv£("H.M„àŽ×fÔîPP˜k8H~$ª©µ¤—˜»Ïþ„×°Á)—Áƒ”&Ãä8>E¸Mwà¸EåÌx=œ>ï ñ�q¹G­õ_ë\"‹&h¸Š~¨d†tiÆZ¢ËÚO1\C�\SÀQ,ú8ç¼"Ë¦½ÕT™ÔYº�×c¾šwOøCÙ¡�8 †÷>•¢Žïj”­lû´�¨Ô¿ùÔF6î—ã¯p:ê×s…4S”Îr(ÀO±Û�Ð[MÝŸ2ªÞ�	ŠÍØÆ~¥[Ù(HW­­ÈƒñÜ¾¿Û@èï,ÔwJ¤r&Z¡Añ2¾hE1$p'¿{>8ó»Ô³€»NpÈñµÝø^K¬5§ùDv! �÷œÓ‘U�-¯øq?–q(‹Æ’Y~:þ_³×€—ñãÊRê¢NH7ÕWú­"§oÎ‡ÇUœl§<5àˆ,À×rofûo·âhÈ‰Ü¾q\àÛNIðkåFÇV½8ˆÀARg³•)mIù¢tqÝœ?™´­ƒHµYÄÇ‹!Ò7ØF� =/?#Á`míË¬¶©ïÅ`N…­	åêa˜£ýV¤‚F²Š«%nñÔQé¿?ðéqm„RšÊ'û+¯±‡…] e�˜ƒú¼cC`! Ã–äéã´Ä¢wè_�Þµ­#0žñ©ÜG™¬Vl‘:I·Ý¢©FÌb4ŠdR5…àqÑ¯ýzˆ˜¨oYGsFl+'â˜†„›ö¢Ã™å~~½¥X�DŠQ‡{ˆü`\ºý5&î©d¸GþB+¼Wÿ S8m<³-Ü¢ñi"šùò©ö~#äXœÐ#Çq¨Fœ~êè°lò9{u!²H,N¸(’ýLï€Ù{´-�Ç=b_'8¡*<bîÒ”AžçÓD¿†D‘qE·í¦�‹(ßÙqù+uIŽáA0?/¯?X•‹i¾ê(º˜M˜¨áˆ�ƒè7€ÛÉS¹à[¼¡—hœtÌ ;/MöEp.¸’]Ij B™ ”C–²B6ù˜ƒÂyZè˜OeNGªrÎO`¼Ž¦tà"gÇwZmÜæ¦='ÝkxÀ §ÆÞ�œ]qY_s„§`8¾ižõöý«çŒ“êJÄ”H`“\c5£ñ�X,NOü2v¯F¼o€öÙWãc)QûoŸ®Þì™SWý%¯’ƒ¼@(Hà}†ãêÕïàÕ/ÔM±!•v n;Ë“¢³¦&5ßÔM½P‹1™h!*Š“c’ñ›A:ÚEÅ|?É9ïñ~ÓŒ–Ñ«F¶Y�„FÑIP@Z…pÈ°¡J}í8Ùá%	3¹Ój·àXA”;ß–ðg–éÄ}ewOé×¥ M²Ç^<ê�ßÓ1\kfÚ}å.!iƒ#<¢_¬+áÁøŠw»žŽHµ¼\|�w¬ƒéñ?>ï*¨Žbv‹UÖŸ'ó+€ Âß½ÆÈd?ÏÔ¿=W,6ËZ{ˆÄz0.ÃÕ#ñ[rÀo†Ë—'ÒTÅ”Æ¹„_§ô¸`TCÂL•t Ñ‘®ULósºf¤AcÛ/¥5Y˜2`±�Ä½^­�ì9põm)3a²Îlèªí
Ïn]%ÀQ%ª/ÒÈiüZ¶�Âr üš�½«Uá"wÇ$E[€vG¶�Æ0þ×¿Ò¬c®‰…Žd¼¬…ŠlÁG®œ•„^´È±eþªVåvbÂí ‚ŒÐÃ³mtWðÉ·>KO>éV3¥vÑÍŒœ»!efH´ÇHÁ¶pî†ÐÒäòCŽyó·}�	?Õ‡÷2þ<å+îWýW´èk¡cVÒÛÁ�EàoŸÝ°<>cÒdì]Ì|¿>sÒj3Y®Ür¯u�Î˜¤~JÜq~ÿ6Æ»Šdø€„ÚÓÒü-Jí–Cqhšé
«˜¤>ÿÅáþ�úwí0ò‡™;R¾x}^tèr9cÎ¯Ç�`{+NÐÒÄKê³2pÞ€ôöå¬Î÷kM)íŸn´�Ð�u	
º4¬ÄÈ@xy0’ŽJ””nY>=A‚›m�…¿€®™c(3Ÿ’¥T�VãX†Ž]öK$?¯õ9@ýN=Ónôd9Ä"j2Fíé©pW!ÿ¾a½¼Ÿ¼r	Ã Ôb?�ÈÓQŠ@—ŽTèÔW- Ñž³:{K³p&˜TÁ2ƒoÁ_$u<EÞõ0Ïye =d�líiÚï<¶NîÙ§þkèZ–]UòØýüâîG¡4GOµ¥üÏ”IÈ[C_,±Ïw{=n#8‚«š–91Éïä@ýxöSg8z;`U/È¤úúÏ:œÁ&P<Pc†|.ª™×¶SG–Y:ŸŸ³¨ÑÌŸ†ôqXJ=ÛQ<¯«Í.•¢á•ÆP“Ê”E^ˆPB’Ëa·¯•µºV.¹ˆ¼é~& d?L’äKAÖŽ­'©eqùúÂÈ"ªªßÁ-6N8ùÞGPxJâEÎÅB… KQpŒàÄU}ÂØy¬–òf Ì:äûÿ"A[¦Ï�ÉYÿÜ®ƒSîsC å¡&½U£TÛ“ldág T)ÌsÅ �C©JG½#W:ÚzîZ¤Cóž D hìj0uÅo¸ñVàžžáTÕ+± ÐYEZõãªjš�ßÆßaóˆm!!uÈ^ö´w»‘šè¯ñ¬�=5”wû‹öM|°2üIÌ®+R<=>­,8•¿œ'qÔžs¸•;ó&”öuV„•Ó°™ñç¶öäÇ°ÛN¯ÔÙüåí…ë>    é´*&æ\ ®�¯ Â)-±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  3Ó<?xml version="1.0"?><Features nextValidID="25"><Feature recentID="0" name="luciferase" directionality="1" translationMW="60644.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3906" maxFusedRunOn="3906"><Segment range="2254-3903" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;synthetic &lt;i&gt;luc2&lt;/i&gt; version of the luciferase gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;firefly luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MEDAKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVDITYAEYFEMSVRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMGISQPTVVFVSKKGLQKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFTTLGYLICGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLIDKYDLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDKPGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILIKAKKGGKIAV"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8346" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7555-8346" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8347-8415" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="2" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5114-5702" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6796-7384" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5776-6009" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6221-6356" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6081-6202" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1921" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="minimal IL-2 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2093-2206" color="#ffffff" type="standard"/><Q name="label"><V text="IL-2 promoter"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;minimal promoter from the human interleukin-2 gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8416-8520" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="6442-6448" color="#ffffff" type="standard"/><Segment range="6449-6466" color="#ffffff" type="standard"/><Segment name="-35" range="6467-6472" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="NFAT binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1966-1995" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;NFAT transcription factor&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;NFAT binding site from the human interleukin 2 (IL-2) gene (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot;&gt;Mattila et al., 1990&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="NFAT binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1996-2025" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;NFAT transcription factor&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;NFAT binding site from the human interleukin 2 (IL-2) gene (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot;&gt;Mattila et al., 1990&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="NFAT binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2026-2055" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;NFAT transcription factor&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;NFAT binding site from the human interleukin 2 (IL-2) gene (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot;&gt;Mattila et al., 1990&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="NFAT binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2056-2085" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;NFAT transcription factor&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;NFAT binding site from the human interleukin 2 (IL-2) gene (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/1702384&quot;&gt;Mattila et al., 1990&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6487-6508" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6394-6410" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6418-6434" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8994-9010" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="Factor Xa site" directionality="2" translationMW="473.53" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5584" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="5510" maxFusedRunOn="5510" detectionMode="exactProteinMatch"><Segment range="5585-5596" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="IEGR"/></Q></Feature><Feature recentID="23" name="PuroR" directionality="1" translationMW="21496.48" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4508-5107" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MTEYKPTVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRHIERVTELQELFLTRVGLDIGKVWVADDGAAVAVWTTPESVEAGAVFAEIGPRMAELSGSRLAAQQQMEGLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADVEVPEGPRTWCMTRKPGA*"/></Q></Feature><Feature recentID="24" name="PGK promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3950-4448" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mouse phosphoglycerate kinase 1 promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ª<Notes>
<UUID>a9606493-5ee7-40b9-a850-0a2359fd11dc</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pLV3-4Ã—NFAT-IL-2-Luc2-PGK-Puro</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="1:2:39">2018.12.21</Created>
<LastModified UTC="2:7:13">2026.3.11</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             Ã<StrandColors><TopStrand><ColorRange range="0..3902" colors="black"/><ColorRange range="3903..3916" colors="blue"/><ColorRange range="3917..5136" colors="orange"/><ColorRange range="5137..9018" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..3902" colors="black"/><ColorRange range="3903..3916" colors="blue"/><ColorRange range="3917..5136" colors="orange"/><ColorRange range="5137..9018" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
